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Synthesis of Alkyl 6-Methyl-4- (2-pyridyl)-1,2,3,4-tetrahydro-2H-pyrimidine-2-one-5-carboxylates for Evaluation as Calcium Channel Antagonists.

โœ Scribed by Kuljeet Kaur; Edward E. Knaus

Book ID
111699732
Publisher
John Wiley and Sons
Year
2007
Weight
18 KB
Volume
38
Category
Article
ISSN
0931-7597

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๐Ÿ“œ SIMILAR VOLUMES

Synthesis of alkyl 6-methyl-4-(2-pyridyl
Synthesis of alkyl 6-methyl-4-(2-pyridyl)-1,2,3,4-tetrahydro-2H-pyrimidine-2-one-5-carboxylates for evaluation as calcium channel antagonists
โœ Kuljeet Kaur; Edward E. Knaus ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 203 KB ๐Ÿ‘ 1 views

## Abstract magnified image The Bigenelli acid catalyzed condensation of 2โ€pyridylcarboxaldehyde (**1**), urea (**2**) and an alkyl acetoacetate (**3**) afforded the respective alkyl (Me, Et, __i__โ€Pr, __i__โ€Bu, __t__โ€Bu) 6โ€methylโ€4โ€(2โ€pyridyl)โ€1,2,3,4โ€tetrahydroโ€2__H__โ€pyrimidineโ€2โ€oneโ€5โ€carboxyl

Synthesis of alkyl 6-methyl-4-(2-trifluo
Synthesis of alkyl 6-methyl-4-(2-trifluoromethylphenyl)-1,2,3,4-tetrahydro-2H-pyrimidine-2-one-5-carboxylates possessing a N-3 nitro substituent to determine calcium channel modulation structure-activity relationships
โœ Kuljeet Kaur; Edward E. Knaus ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 255 KB ๐Ÿ‘ 1 views

The Bigenelli acid catalyzed condensation of 2-trifluoromethylbenzaldehyde (1), urea (2) and an alkyl acetoacetate (3) afforded the respective alkyl (Me, Et, i-Pr, i-Bu) 6-methyl-4-(2-trifluoromethylphenyl)-1,2,3,4-tetrahydro-2H-pyrimidine-2-one-5-carboxylate (4-7). Subsequent N 3 -nitration of the