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Synthesis of 6-/N,N-1′,6′-hexyleneformamidine-14C/-penicillanic acid

✍ Scribed by Janina Zupanska; Krystina Szymoniak; Irena Busko-Oszczapowicz; Jerzy Cieslak

Publisher: John Wiley and Sons
Year: 1974
Tongue: French
Weight: 152 KB
Volume: 10
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590100310

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✦ Synopsis

Abstract

Synthesis of 6‐/N,N‐1′, 6′‐hexyleneformamidine‐^14^C/penicillanic acid /VII/ was carried out. N‐formyl‐^14^C‐hexamethyleneimine /II/ was obtained from formic‐14C acid and hexamethyleneimine /I/. The product was chlorinated with oxalyl chloride. The obtained N,N‐1, 6‐hexylenechloroformimino‐^14^C chloride /III/ was condensed with trimethylsilyl ester of N‐trimethylsilyl‐6‐amino penicillanic acid /V/. The final product /VII/ was separated with a radiochemical yield of 46.5%.

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