Synthesis of 6-azaprogesterone and 19-hydroxy-6-azasteroids
✍ Scribed by Mario D. Martínez; Valeria C. Edelsztein; Fernando J. Durán; Pablo H. Di Chenna; Gerardo Burton
- Book ID
- 119373859
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 304 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0039-128X
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A novel Mannich type condensation between the monomethyl ester of acetonedicarboxylic acid, methylamine hydrochloride, and hydrolyzed dimethoxydihydrothran gave 6-or 7-functionalized flketo ester tropanes 12 -15. Further elaboration afforded a series of 6-or 7-hydroxy and 6-or 7methoxy 21~-methoxyca