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Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity

✍ Scribed by Kusano, Shuhei; Sakuraba, Tomoya; Hagihara, Shinya; Nagatsugi, Fumi


Book ID
122011315
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
567 KB
Volume
22
Category
Article
ISSN
0960-894X

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We previously reported that oligodeoxynucleotides containing 2-amino-6-vinylpurine (2-AVP: 1) exhibit efficient selective cross-linking to cytosine. In this study, the 2 0 -OMe nucleoside analogue (2) of 2-AVP was designed in order to increase its affinity to RNA and enhance metabolic stability. It

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