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Synthesis and biological evaluation of new 2-amino-6-(trifluoromethoxy)benzoxazole derivatives, analogues of riluzole

✍ Scribed by Calabrò, Maria Luisa; Caputo, Rosanna; Ettari, Roberta; Puia, Giulia; Ravazzini, Federica; Zappalà, Maria; Micale, Nicola


Book ID
120456531
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
535 KB
Volume
22
Category
Article
ISSN
1054-2523

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The synthesis and in vitro evaluation of a new series of salvinorin A analogues substituted at the C(2) position with natural amino acids is reported. Compound 12, containing Val, displayed high affinity and full agonist activity at the kappa-opioid receptor. Analogues with bulky and/or aromatic res