Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral Activity
β Scribed by Hagen, Susan E.; Vara Prasad, J. V. N.; Boyer, Frederick E.; Domagala, John M.; Ellsworth, Edmund L.; Gajda, Christopher; Hamilton, Harriet W.; Markoski, Larry J.; Steinbaugh, Bruce A.; Tait, Bradley D.; Lunney, Elizabeth A.; Tummino, Peter J.; Ferguson, Donna; Hupe, Donald; Nouhan, Carolyn; Gracheck, Stephen J.; Saunders, James M.; VanderRoest, Steven
- Book ID
- 127025712
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 157 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
The first asymmetric synthesis of potential cyclic urea HIV protease inhibitors of Type 2 is reported. The synthesis is short and highly versatile in the choice of the substitution pattern and absolute configuration of the products starting from readily available materials. Nonchiral central buildin
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