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Synthesis of [5,6-3H2]CP-88,818 (β-[5,6-3H2]tigogenin cellobioside)

✍ Scribed by Peter A. McCarthy

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
417 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

CP‐88,818 (β‐tigogenin cellobioside) is a novel hypocholesterolemic and anti‐atherosclerosis agent which acts by inhibiting the absorption of dietary and biliary cholesterol. While the exact mechanism of this inhibition is unclear, CP‐88,818 is believed to block cholesterol absorption without entering the body. In order to prove this hypothesis, radiolabelled CP‐88,818 was needed. Herein, we report the stereoselective synthesis of [5,6‐^3^H~2~]CP‐88,818 in four steps from diosgenin acetate.

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