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Synthesis of 5,5-Diphenyl-4-penten-2-one: A Variation on a Classic Organic Synthesis Laboratory

✍ Scribed by Alber, Joshua P.; DeGrand, Michael J.; Cermak, Diana M.


Book ID
121500061
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
636 KB
Volume
88
Category
Article
ISSN
0021-9584

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b-Lactam (Β±)-N-benzyl-4-phenyl-azetidin-2-one rac-6a was converted into the g-lactam (Β±)-trans-4,5-diphenyl-pyrrolidin-2-one rac-5 which was resolved via the preparation of diastereomers with N-phthalyl-L-alanine chloride or D-alanine chloride and its absolute configuration was determined by X-ray c