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Synthesis of (±)-5,10-methenyltetrahydrofolic acid-214C and (±)-5-formyltetrahydrofolic acid-214C

✍ Scribed by J.R.G. Beavon; J.A. Blair


Book ID
107711211
Publisher
Elsevier Science
Year
1971
Tongue
English
Weight
194 KB
Volume
44
Category
Article
ISSN
0003-2697

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Synthesis of the title compound, C14 labeled CP-73,850 (zopolrestat), was accomplished by condensation of 1-phthalazineacetic acid, 3-14C cyanomethyl-3,4-dihydr0-4-0~0-, ethyl ester with 3-amino-4-mercapto-benzotrifluoride, followed by base hydrolysis of the resultant product, 1-phthalazineacetic ac