Synthesis of 5-substituted uracils and 2,4-dimethoxypyrimidines by wittig olefination
β Scribed by Evdoxia Coutouli-Argyropoulou; Christina Zachariadou
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2005
- Tongue
- English
- Weight
- 135 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-152X
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π SIMILAR VOLUMES
Sumnary: A highly efficient and general method for the synthesis of 5-(2-acylethynyl)-2,4dimethoxypyrimidines starting from 2,4-dimethoxy-5-/?r(brimethylsilyl)ethynyl~pyrimidine is described. The 5-(2-acylethynyl)-2,4-dimethoxypyrimidines have b?en converted to 5-(2-acyl-l-iodovinyl) uracils and 5-(
The rhodium(I)-catalysed sequential silylformylation/Wittig olefination of terminal alkynes with hydrosilanes and carbon monoxide in the presence of stabilised P-ylides leads to substituted 2,4-dienoic esters in a one-pot procedure. The