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Synthesis of 5-substituted indole derivatives. Part 3: A facile synthesis of 5-chloromethyl-1H-indole-2-carboxylates: replacement of sulfonic acid functionality by chlorine

✍ Scribed by Béla Pete; László Tőke

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
71 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Valuable new synthetic intermediates, 5-chloromethyl-1H-indole-2-carboxylates, were prepared by the elimination of SO 2 from 2-ethoxycarbonyl-1H-indole-5-methanesulfonic acids, which are easily accessible by Fischer-type indolization.

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A facile synthesis of 7-chloromethyl-1H-
A facile synthesis of 7-chloromethyl-1H-indole-2-carboxylates: Replacement of a sulfonic acid functionality by chlorine
✍ Béla Pete; Frigyes Varga; János Kovács 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 67 KB

Valuable new synthetic intermediates, 7-chloromethyl-1H-indole-2-carboxylates (3a-d), were prepared by the facile elimination of sulfur dioxide under the influence of thionyl chloride from 2-ethoxycarbonyl-1H-indole-7-methanesulfonic acids (1a-d), easily accessible by Fischer-type indolisation. The