A facile synthesis of 4- and 6-chloromethyl-1H-indole-2-carboxylates: replacement of a sulfonic acid functionality by chlorine
✍ Scribed by Béla Pete; Gyula Parlagh
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 143 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Valuable new synthetic intermediates, 7-chloromethyl-1H-indole-2-carboxylates (3a-d), were prepared by the facile elimination of sulfur dioxide under the influence of thionyl chloride from 2-ethoxycarbonyl-1H-indole-7-methanesulfonic acids (1a-d), easily accessible by Fischer-type indolisation. The
Valuable new synthetic intermediates, 5-chloromethyl-1H-indole-2-carboxylates, were prepared by the elimination of SO 2 from 2-ethoxycarbonyl-1H-indole-5-methanesulfonic acids, which are easily accessible by Fischer-type indolization.
## Abstract magnified image Valuable new synthetic intermediates, 5(6)‐(chloromethyl)benzimidazoles, were prepared by the facile elimination of sulfur dioxide under the influence of thionyl chloride from benzimidazole‐5(6)‐methane‐sulfonic acids easily obtained from (3,4‐diaminophenyl)methanesulfo