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Synthesis of 5-Substituted 1H-Tetrazoles by the Copper-Catalyzed [3+2] Cycloaddition of Nitriles and Trimethylsilyl Azide
β Scribed by Tienan Jin; Fukuzou Kitahara; Shin Kamijo; Yoshinori Yamamoto
- Book ID
- 112005510
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 302 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1861-4728
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π SIMILAR VOLUMES
The [3+2] cycloaddition between various nitriles and trimethylsilyl azide proceeds smoothly in the presence of a Cu I catalyst in DMF/ MeOH, to give the corresponding 5-substituted 1H-tetrazoles in good to high yields. The reaction most probably proceeds through the in situ formation of a copper azi
A variety of 2-allylated-5-substituted tetrazoles were prepared in excellent yields through the reaction of alkyland arylidenemalononitriles, allyl acetates and trimethylsilyl azide in the presence of a palladium catalyst.