Regiospecific synthesis of 2-allylated-5-substituted tetrazoles via palladium-catalyzed reaction of nitriles, trimethylsilyl azide, and allyl acetates
β Scribed by Young Soo Gyoung; Jae-Goo Shim; Yoshinori Yamamoto
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 137 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A variety of 2-allylated-5-substituted tetrazoles were prepared in excellent yields through the reaction of alkyland arylidenemalononitriles, allyl acetates and trimethylsilyl azide in the presence of a palladium catalyst.
π SIMILAR VOLUMES
The [3+2] cycloaddition between various nitriles and trimethylsilyl azide proceeds smoothly in the presence of a Cu I catalyst in DMF/ MeOH, to give the corresponding 5-substituted 1H-tetrazoles in good to high yields. The reaction most probably proceeds through the in situ formation of a copper azi
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