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Synthesis of 5-phosphate-D-arabinohydroxamic acid, a potent transition state analogue inhibitor of 6-phosphate-D-glucose isomerases

โœ Scribed by Corinne Bonnette; Laurent Salmon; Alain Gaudemer


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
237 KB
Volume
37
Category
Article
ISSN
0040-4039

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Stereoselective synthesis of 5-methylpho
โœ Corentin Le Camus; Alexia Chassagne; Marie-Ange Badet-Denisot; Bernard Badet ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 113 KB

Compound 2, synthesized from D-arabinose in 12 steps with an overall 4% yield, is a competitive inhibitor vs fructose-6P for both phosphoglucose isomerase and glucosamine-6P synthase.