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Stereoselective synthesis of 5-methylphosphono-D-arabino hydroximolactone, inhibitor of glucosamine-6-phosphate synthase and phosphoglucose isomerase

✍ Scribed by Corentin Le Camus; Alexia Chassagne; Marie-Ange Badet-Denisot; Bernard Badet

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 113 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)10514-7

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✦ Synopsis

Compound 2, synthesized from D-arabinose in 12 steps with an overall 4% yield, is a competitive inhibitor vs fructose-6P for both phosphoglucose isomerase and glucosamine-6P synthase.

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