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Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to D -2′-Deoxy-2′-α-fluoro-2′-β- C -methyl Nucleosides

✍ Scribed by Pradere, Ugo; Amblard, Franck; Coats, Steven J.; Schinazi, Raymond F.


Book ID
123619382
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
352 KB
Volume
14
Category
Article
ISSN
1523-7060

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2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′,5′
✍ P. Ganapati Reddy; Donghui Bao; Wonsuk Chang; Byoung-Kwon Chun; Jinfa Du; Dhanap 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 808 KB

A series of novel 2 0 -deoxy-2 0 -a-fluoro-2 0 -b-C-methyl 3 0 ,5 0 -cyclic phosphate nucleotide prodrug analogs were synthesized and evaluated for their in vitro anti-HCV activity and safety. These prodrugs demonstrated a 10-100-fold greater potency than the parent nucleoside in a cell-based replic