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Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents

โœ Scribed by Gangjee, Aleem; Shi, Jufang; Queener, Sherry F.; Barrows, Louis R.; Kisliuk, Roy L.


Book ID
126429732
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
1013 KB
Volume
36
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Nonclassical 2,4-Di
โœ C. ROBSON; M. A. MEEK; J.-D. GRUNWALDT; P. A. LAMBERT; S. F. QUEENER; D. SCHMIDT ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 1 views

Nonclassical 2,4-Diamino-5-aryl-6-ethylpyrimidine Antifolates: Activity as Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents. -Title compounds such as (I) exhibit potent inhibitory activity against dihydrofolate reductase (DHFR) from Toxop