Synthesis and biological properties of s
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Hisashi Miyamoto; Hiroshi Yamashita; Hiraki Ueda; Hisashi Tamaoka; Kazunoli Ohmo
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Article
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1995
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Elsevier Science
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English
β 677 KB
A series of substituted 1-cyclopropyl-6-fluoro-1, 4-dihydro-5-methyl-4-oxo-3-quinoline carboxylic acids was synthesized and tested for their in vitro and in vivo antibacterial activity. The introduction of a methyl group at the 5-position of quinoline nucleus enhanced characteristically the antibact