Synthesis of 5-Hydroxypipecolic Acid and Separation of Its Diastereoisomers
✍ Scribed by COHEN, L. A.; IRREVERRE, F.; PIEZ, K. A.; WITKOP, B.; WOLFF, H. L.
- Book ID
- 121148623
- Publisher
- American Association for the Advancement of Science
- Year
- 1956
- Tongue
- English
- Weight
- 129 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0036-8075
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## Abstract The synthesis is described of 5‐hydroxypipecolic acid by reduction with sodium borohydride of the corresponding keto‐acid, which in turn was prepared from glutamic acid. This reduction proceeds without any appreciable formation of __allo__‐isomer. The optical resolution is also describ
## Abstract A new synthetic route to enantiopure (2__S__,4__R__)‐4‐hydroxypipecolic acid from commercial ethyl (3__S__)‐4‐chloro‐3‐hydroxybutanoate is reported. The synthesis is based on the Pd‐catalyzed methoxycarbonylation of a 4‐alkoxy‐substituted δ‐valerolactam‐derived vinyl triflate followed b