Synthesis of Phosphonic Analogues of 4-Hydroxyproline and 5-Hydroxypipecolic Acid
✍ Scribed by El Khalabi, R.; El Hallaoui, A.; Ouazzani, F.; Elachqar, A.; Atmani, A.; Roumestant, M. L.; Viallefont, Ph.; Martinez, J.
- Book ID
- 120809256
- Publisher
- Taylor and Francis Group
- Year
- 2000
- Tongue
- English
- Weight
- 392 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1082-6068
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## Abstract A new synthetic route to enantiopure (2__S__,4__R__)‐4‐hydroxypipecolic acid from commercial ethyl (3__S__)‐4‐chloro‐3‐hydroxybutanoate is reported. The synthesis is based on the Pd‐catalyzed methoxycarbonylation of a 4‐alkoxy‐substituted δ‐valerolactam‐derived vinyl triflate followed b
## Abstract The synthesis is described of 5‐hydroxypipecolic acid by reduction with sodium borohydride of the corresponding keto‐acid, which in turn was prepared from glutamic acid. This reduction proceeds without any appreciable formation of __allo__‐isomer. The optical resolution is also describ