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Synthesis of 5-fluorovinyl derivatives of pyrimidines via Suzuki–Miyaura coupling and their 1,3-dipolar cycloaddition reactions with nitrones

✍ Scribed by Hanna Wójtowicz-Rajchel; Henryk Koroniak


Book ID
113711603
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
618 KB
Volume
135
Category
Article
ISSN
0022-1139

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## Abstract magnified image Asymmetric 1,3‐dipolar cycloadditions of chiral nitrones to 1‐propene‐1,3‐sultone (**1**) were investigated. Chiral nitrones **6a‐e** reacted with sultone **1** in toluene at 90 °C for 24‐36 h to give the corresponding isoxazolidines in moderate yields with high regiose