Synthesis of 5-(aroylamino)-2-methyl-2H,-1,2,4-thiadiazol-3-ones by oxidative cyclization of 1-aroyl-5-methyl-2-thiobiurets
✍ Scribed by Nam Sook Cho; Hyun Il Shon; Cyril Párkányi
- Book ID
- 112130150
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1991
- Tongue
- English
- Weight
- 280 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Starting from 5‐hydroxymethyl‐2‐mercapto‐1‐methyl‐1__H__‐imidazole (1), a series of 2‐(1‐methyl‐2‐methylsulfonyl‐1__H__‐imidazol‐5‐yl)‐5‐alkylthio and 5‐alkylsulfonyl‐1,3,4‐thiadiazole derivatives (**9a**, **9b**, **9c**, **9d** and **10a**, **10b**, **10c**, **10d**) were prepared as p
## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l