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Synthesis of 5-alkoxy-4-amino-3-bromo-2(5H)-furanones containing benzene rings

✍ Scribed by Fu-Ling Xue, Jian-Xiao Li, Zhao-Yang Wang…


Book ID
120765665
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
695 KB
Volume
39
Category
Article
ISSN
0922-6168

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Easily available 3,4-dibromo-2(5H)-furanone undergoes a regioselective cross-coupling reaction with alkylboronic acids in the presence of catalytic amounts of PdCl2(MeCN)2 and AsPh3 and a large molar excess of Ag2O to provide the corresponding 4-alkyl-3-bromo-2(5H)-furanones in satisfactory yields.