Antineoplastic agents. 58. Synthesis of 3-aryl-5-bromo-2(5H)-furanones
✍ Scribed by Edgar, Mark T.; Pettit, George R.; Smith, Thomas H.
- Book ID
- 121493636
- Publisher
- American Chemical Society
- Year
- 1978
- Tongue
- English
- Weight
- 909 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## Abstract 3(2‐pyridinylmethylene)‐5‐aryl‐2(3__H__)‐furanones and 3(3‐pyridinylmethylene)‐5‐aryl‐2(3__H__)‐furanones were prepared as a mixture of (E) and (Z) stereoisomers by condensing pyridine‐2‐carboxaldehyde and pyridine‐3‐carboxaldehyde with 3‐aroylpropionic acids. The reaction of the furano
## Abstract Highly optically active 4‐substituted‐2(5__H__)‐furanones 6a‐6j were obtained in good yields with __de__⩾98% by the tandem Michael addition/elimination reaction of chiral 3‐bromo‐2(5__H__)‐furanone (4a), which was conveniently prepared starting from 2‐furaldehyde under mild conditions.