## Abstract 3(2‐pyridinylmethylene)‐5‐aryl‐2(3__H__)‐furanones and 3(3‐pyridinylmethylene)‐5‐aryl‐2(3__H__)‐furanones were prepared as a mixture of (E) and (Z) stereoisomers by condensing pyridine‐2‐carboxaldehyde and pyridine‐3‐carboxaldehyde with 3‐aroylpropionic acids. The reaction of the furano
✦ LIBER ✦
Synthesis and evaluation of 5-arylated 2(5H)-furanones and 2-arylated pyridazin-3(2H)-ones as anti-cancer agents
✍ Scribed by Eric Lattmann; Washington O. Ayuko; Derek Kinchinaton; Christopher A. Langley; Harjit Singh; Leila Karimi; Michael J. Tisdale
- Book ID
- 111768861
- Publisher
- Pharmaceutical Press
- Year
- 2003
- Tongue
- English
- Weight
- 246 KB
- Volume
- 55
- Category
- Article
- ISSN
- 2042-7158
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## Abstract 3,4‐Dichloro‐2(5__H__)‐furanone, which has been prepared efficiently from mucochloric acid, has been transformed selectively into 4‐aryl‐3‐chloro‐2(5__H__)‐furanones either by Suzuki‐ or Stille‐type reactions. These monochloro derivatives have been used as precursors either to (__Z__)‐4