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Synthesis of 5-(4′-carboxyphenyl)-10,15,20-tris-(4 pyridyl)-porphyrin and its peptidyl phosphonate derivatives

✍ Scribed by Jan Habdas; Bogdan Boduszek

Book ID
105359752
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
136 KB
Volume
15
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

The synthesis and characterization of three new 4‐pyridyl porphyrin‐peptidyl‐phosphonate compounds, containing a diphenyl 3‐pyridylmethyl‐phosphonate moiety, is described in this article. Nitrogen atoms in the pyridine rings of the obtained compounds were alkylated using methyl iodide, to give additional three, water soluble derivatives of these peptidyl‐porphyrin conjugates. All the synthesized compounds could serve as potential photosensitizers for the photodynamic therapy (PDT) method of tumor therapy and displayed activity as inhibitors of aminopeptidase N. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.

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Synthesis of peptidyl phosphonates conta
Synthesis of peptidyl phosphonates containing 5-(4′-carboxyphenyl)-10,15,20-tritolylporphyrin
✍ Jan Habdas; Bogdan Boduszek 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB

## Abstract The synthesis and characterization of three new porphyrin‐peptidyl‐phosphonate derivatives, containing a diphenyl 3‐pyridylmethyl‐phosphonate moiety, is described. These compounds could serve as potential photosensitizers for the PDT method of tumor therapy and displayed activity as inh