Synthesis of 5-11C]methyl-3-[[2(S)-azetidinyl]methoxy]-pyridine, an analogue of A-85380 for in vivo studies of nicotinic receptor
✍ Scribed by F. Karimi; M. Björkman; B. Långström
- Book ID
- 112132821
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 53 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2135
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## Abstract 3‐[(2S)‐azetidin‐2‐ylmethoxy]‐5‐[^11^C]‐methylpyridine **(5d)**, which might be a novel ligand for nicotinic receptors, was synthesized via coupling [^11^C]iodomethane with __tert__‐butyl (2S)‐2‐({[5‐(trimethylstannyl)pyridin‐3‐yl]oxy}methyl) azetidine‐1‐carboxylate **(4)** at 80°C for
## 5-((1-[ ]-methyl iodide and the corresponding normethyl precursor. The average time of synthesis, purification, and formulation was 42 min with an average non-decay-corrected radiochemical yield of 19%. The average specific radioactivity was 359 GBq/mmol (9691 mCi/mmole) at end of synthesis (EO
## Abstract 6‐Chloro‐3‐((2‐(__S__)‐azetidinyl)methoxy)‐5‐(2‐[^18^F]fluoropyridin‐4‐yl)pyridine ([^18^F]NIDA 522131), a potential radioligand for studying extrathalamic nicotinic acetylcholine receptors by positron‐emission tomography, was synthesized via no‐carrier‐added nucleophilic [^18^F]fluorin