Synthesis of 4,7,8a,9-tetrahydro-3H-diimidazo-[1,5-a:4′,5′-d]pyridine derivatives
✍ Scribed by Miguel F. Braña; Cristina Guisado; Javier Pérez-Castells; Leticia Pérez-Serrano
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2002
- Tongue
- English
- Weight
- 34 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
The synthesis and evaluation of new ligands for the H~3~ receptor of histamine is described. These new compounds are diimidazopyridine derivatives readily prepared by a condensation reaction of spinacine and isocyanates.
📜 SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract The synthesis of new ligands for the H~3~ histamine receptor is described. These new compounds are spinacine derivatives obtained by alkylation or Michael reaction at C6 position.
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Reaction of 5‐amino‐3‐methyl‐1‐phenylpyrazole (1a) and 5‐amino‐3‐(4‐chlorophenyl)‐1__H__‐pyrazole (1b) with dimedone (2) and __p__‐susbstituted benzaldehydes 3 in ethanol, afforded in all cases tricyclic linear 4‐aryl‐7,7‐dimethyl‐4,7,8,9‐tetrahydro‐6__H__‐pyrazolo[3,4‐__b__]quinolin‐5‐
## Abstract via acid‐catalyzed acylation of 2‐amino‐tetrahydrochromene‐3‐carboxylates (I)