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Synthesis of 4-monofluoromethylenyl- and cis-4-monofluoromethyl-l-pyroglutamic acids via a novel dehydrofluorination

✍ Scribed by Xiao-Long Qiu; Wei-Dong Meng; Feng-Ling Qing


Book ID
108282583
Publisher
Elsevier Science
Year
2004
Tongue
French
Weight
256 KB
Volume
60
Category
Article
ISSN
0040-4020

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ChemInform Abstract: New Amino Acids Der
✍ J. VAN BETSBRUGGE; W. VAN DEN NEST; P. VERHEYDEN; D. TOURWE πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 38 KB πŸ‘ 2 views

Pyroglutamic acid derivative (I) is proved to be an excellent chiral starting compound for the synthesis of title amino acids (IX), (X), and (V). The syntheses are based on a combination of methods previously used for the preparation of 4-and 5-substituted prolines. These methods are the ring openin