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Synthesis of 4-hydroxycoumarin derivatives-1: An efficient synthesis of Flocoumafen

โœ Scribed by Oee Sook Park; Bong Suek Jang


Book ID
112961133
Publisher
Springer
Year
1995
Tongue
English
Weight
421 KB
Volume
18
Category
Article
ISSN
0253-6269

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Efficient synthesis of trisubstituted [1
โœ Yuan-Xiu Liao; Pei-Yu Kuo; Ding-Yah Yang ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 128 KB

Various trisubstituted [1]benzopyrano[4,3-b]pyrrol-4(1H)-one derivatives have been synthesized from 4-hydroxycoumarin with a 30-40% yield over six steps. The key step of the synthesis is a base-promoted intramolecular cyclization of enamines 5, followed by dehydration to generate the fused pyrrole r