Synthesis of 4-chlorobicyclo[2.2.0]hexane-1-carboxylic acid
β Scribed by Kirby V. Scherer Jr.
- Book ID
- 108383250
- Publisher
- Elsevier Science
- Year
- 1966
- Tongue
- French
- Weight
- 199 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The thermal isomerization of the title compounds was studied in the vapor phase. Over the temperature range from 445.1 to 477.5"K7 1,4-dimethylbicyclo[2.2.O]hexane underwent a homogeneous unimolecular reaction to 2,5-dimethyl-175-hexadiene, the rate constants being represented by the equation: k =
As part of a program aimed at the design of conformationally constrained analogs of glutamic acid, (+)-2-aminobicyclo[3.1.0]hexane-2,6-carboxylic acid (1), identified as a highly potent, selective, group II metabotropic glutamate receptor agonist has been synthesized and studied clinically. Heterocy