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Synthesis of 4-Aza Analogues (I) of Epothilone D.

โœ Scribed by Frederic Cachoux; Franck Schaal; Antje Teichert; Trixie Wagner; Karl-Heinz Altmann


Publisher
John Wiley and Sons
Year
2005
Weight
12 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract __A green fluorescent 12โ€azaโ€epothilone (azathilone) derivative has been prepared through the attachment of the 4โ€nitroโ€2,1,3โ€benzoxadiazole (NBD) fluorophore to the 12โ€nitrogen atom of the azamacrolide core structure. While less potent than natural epothilones or different N12โ€acylated