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Synthesis and Biological Evaluation of Aza-Epothilones

✍ Scribed by Dieter Schinzer; Karl-Heinz Altmann; Friedrich Stuhlmann; Armin Bauer; Markus Wartmann


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
125 KB
Volume
1
Category
Article
ISSN
1439-4227

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A new class of porphyrins bearing thioglycosyl groups is presented in order to improve targeting of malignant cells and resistance to glycosidases. These compounds were synthesized in four steps. They produced 1 O 2 and their photocytotoxicity against the yeast Saccharomyces cerevisiae was compared