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Synthesis and biological evaluation of thioglycosylated meso-arylporphyrins

✍ Scribed by Isabelle Sylvain; Rachida Benhaddou; Vincent Carre; Sylvain Cottaz; Hugues Driguez; Robert Granet; Michel Guilloton; Pierre Krausz

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
54 KB
Volume
03
Category
Article
ISSN
1088-4246

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✦ Synopsis

A new class of porphyrins bearing thioglycosyl groups is presented in order to improve targeting of malignant cells and resistance to glycosidases. These compounds were synthesized in four steps. They produced 1 O 2 and their photocytotoxicity against the yeast Saccharomyces cerevisiae was compared with the effect of haematoporphyrin.

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