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Synthesis of 4-amino(desoxy)-10-methylpteroyl-L-glutamic acid

โœ Scribed by V. M. Berezovskii; G. D. Glebova; E. M. Birinberg; L. V. Kazanskaya


Book ID
111915809
Publisher
Springer
Year
1968
Tongue
English
Weight
281 KB
Volume
2
Category
Article
ISSN
0091-150X

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Asymmetric synthesis of L-[4-13C]glutami
โœ Kazuhiko Takatori; Takuya Sakamoto; Masahiro Kajiwara ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 123 KB

l-[4-l3 C]Glutamic acid (1) and l-[4-13 C]glutamine (2) were synthesized from sodium [2-13 C]acetate (5) and Dellaria's oxazinone 3 as a chiral glycine equivalent. Sodium [2-13 C]acetate (5) was converted to [2-13 C]acrylate 4. Diastereoselective Michael addition of the enolate of 3 to the acrylate