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Synthesis of 4′-amino-4′-deoxy analog of pantothenic acid

✍ Scribed by V.M. Kopelevich; L.N. Bulanova; V.I. Gunar

Book ID
104246552
Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
150 KB
Volume
20
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of g-and &-N-(4-amino-3, 3-dimethyl-2-hydroxybutyryl)-j-alanine (1) is described. Compound 1 is an analog of pantothenic acid in which the 4'-hyroxy group is replaced by ami no group. The synthetic sequence leading to 7 involved the syntheais ;L-4-amino-3,3-dimethyl-2-hydroxybutyric acid and its resolution. Coupling of N-benzyloxycarbonyl N-hydroxysuccinimide ester (5) with F-alanine and followed by removal of the protecting group gave z.

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