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Analogs of D(+)-pantothenic acid. VI. Synthesis of D-, L-, and DL-4′-amino-4′-deoxypantothenic acid

✍ Scribed by V. M. Kopelevich; L. N. Bulanova; V. I. Gunar

Book ID
112377420
Publisher
Springer
Year
1982
Tongue
English
Weight
606 KB
Volume
18
Category
Article
ISSN
0009-3130

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Synthesis of 4′-amino-4′-deoxy analog of
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## 5-Alkyl derivatives of dl-tetrahydromethotrexate have been prepared by reduction of methotrexate by sodium borohydride followed by reductive condensation with aldehyde and sodium borohydride and formation of the calcium salt (l-3). ## Methods Chemicals were obtained as follows: methotrexate,