Two synthetic routes to the versatile 3,5-dihydro-imidazo [4,5-d]pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of the heteroaromatic scaffolds has also been accompli
Synthesis of 4-alkyl-3,5-dibromo-, 3-bromo-4,5-dialkyl- and 3,4,5-trialkylpyridines via sequential metalation and metal-halogen exchange of 3,5-dibromopyridine
β Scribed by Yu Gui Gu; Erol K. Bayburt
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 202 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The synthesis of the polyhalogenated phenylalanines Phe(3β²,4β²,5β²βBr~3~) (**3**), Phe(3β²,5β²βBr~2~β4β²βCl) (**4**) and DLβPhe (2β²,3β²,4β²,5β²,6β²βBr~5~) (**9**) is described. The trihalogenated phenylalanines **3** and **4** are obtained stereospecifically from Phe(4β²βNH~2~) by electrophilic b
Easily available 3,4-dibromo-2(5H)-furanone undergoes a regioselective cross-coupling reaction with alkylboronic acids in the presence of catalytic amounts of PdCl2(MeCN)2 and AsPh3 and a large molar excess of Ag2O to provide the corresponding 4-alkyl-3-bromo-2(5H)-furanones in satisfactory yields.