Asymmetric synthesis of (2s)-and (2R)-4-(3-t-butylamino-2-hydroxypropoxy)-benzimidazol-2-[~1C]-one ((S)-and (R)-[11C]-CGP 12177) from optically active precursors Akli HAMMADI, Christian CROUZEL
Synthesis of 4-(3-t-butylamino-2-hydroxypropoxy)-benzimidazol-2(11c)-one (cgp 12177)
โ Scribed by C Boullais; C Crouzel; A Syrota
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- French
- Weight
- 97 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-2135
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โฆ Synopsis
BENZIMIDAZOL-2 ("C)-ONE (CGP 12177)
B o u l l a i s C., Crouzel C., Syrota A .
๐ SIMILAR VOLUMES
S-[1-(2,3-Diaminophenoxy)]-3'-(N-t-butylamino)propan-2'-ol has been synthesized in three steps from 2,3-dinitro-phenol and the chiral auxiliary, S-glycidyl-3-nitrobenzenesulphonate, to provide a precursor for labelling S-(3'-t-butylamino-2'-hydroxypropoxy)-benzimidazol-2-one (S-CGP 12177) with the s
## Abstract A simple and convenient synthesis of a radiolabeled antihypertensive pyridazinone was developed. The product was purified chromatographically, and the chemical and radiochemical purities of the sample were determined.