Rapid analysis for metabolites of 11C-labelled drugs: fate of [11C]-S-4-(tert.-butylamino-2-hydroxypropoxy)-benzimidazol-2-one in the dog

Asymmetric synthesis of a precursor for

Asymmetric synthesis of a precursor for the automated radiosynthesis of S-(3′-t-butylamino-2′-hydroxypropoxy)- benzimidazol-2-[11C]one (S-[11C]CGP 12177) as a preferred radioligand for β-adrenergic receptors

✍ Frank Brady; Sajinder K. Luthra; Henri-J. Tochon-Danguy; Colin J. Steel; Stephen 📂 Article 📅 1991 🏛 Elsevier Science ⚖ 810 KB

S-[1-(2,3-Diaminophenoxy)]-3'-(N-t-butylamino)propan-2'-ol has been synthesized in three steps from 2,3-dinitro-phenol and the chiral auxiliary, S-glycidyl-3-nitrobenzenesulphonate, to provide a precursor for labelling S-(3'-t-butylamino-2'-hydroxypropoxy)-benzimidazol-2-one (S-CGP 12177) with the s