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Synthesis of 4-(1-Alkenyl)isoquinolines by Palladium(II)-Catalyzed Cyclization/Olefination

✍ Scribed by Huang, Qinhua; Larock, Richard C.


Book ID
126068461
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
233 KB
Volume
68
Category
Article
ISSN
0022-3263

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Synthesis of isoquinolines by palladium-
✍ Qinhua Huang; Richard C. Larock πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 131 KB

A variety of 4-(1-alkenyl)-3-arylisoquinolines have been prepared by the Pd(II)-catalyzed cyclization of 2-(1alkynyl)benzaldimines, followed by alkenylation (Heck reaction) in good to excellent yields. The introduction of an ortho-methoxy group on the benzaldimine promotes the Pd-catalyzed cyclizati