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Synthesis of 2-Substituted 3-Alkenyl-indoles by the Palladium-catalyzed Cyclization Followed by Alkenylation (Heck Reaction)

✍ Scribed by Sakamoto, Takao; Yasuhara, Akito; Kaneko, Masashi


Book ID
125429648
Publisher
Japan Institute of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
190 KB
Volume
48
Category
Article
ISSN
0385-5414

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A variety of 4-(1-alkenyl)-3-arylisoquinolines have been prepared by the Pd(II)-catalyzed cyclization of 2-(1alkynyl)benzaldimines, followed by alkenylation (Heck reaction) in good to excellent yields. The introduction of an ortho-methoxy group on the benzaldimine promotes the Pd-catalyzed cyclizati