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Synthesis of [35S]aryl sulfonyl chlorides from [35S]elemental sulfur

✍ Scribed by Michael A. Wallace; Conrad E. Raab; Dennis C. Dean; David G. Melillo

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
111 KB
Volume
48
Category
Article
ISSN
0022-2135

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✦ Synopsis

A new synthetic methodology that captures electrophilic 35 S 8 with aryl Grignard reagents or lithiates provides entry to a wide variety of [ 35 S]aryl sulfonyl chlorides upon oxidation and chlorination.

πŸ“œ SIMILAR VOLUMES

Synthesis of aryl [35S]sulfones: Friedel
Synthesis of aryl [35S]sulfones: Friedel–Crafts sulfonylation of aryl ethers with high specific activity [35S]methanesulfonyl chloride
✍ Michael A. Wallace; Conrad Raab; Dennis Dean; David Melillo πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 French βš– 80 KB

## Abstract Lewis acid‐assisted sulfonylation of anisole with [^35^S]methanesulfonyl chloride afforded high specific activity aryl [^35^S]sulfones. Demethylation and treatment with triflic anhydride gave the versatile [^35^S]triflate **1** in good overall yields. The [^35^S]sulfone triflate could b