✦ LIBER ✦
Synthesis of aryl [35S]sulfones: Friedel–Crafts sulfonylation of aryl ethers with high specific activity [35S]methanesulfonyl chloride
✍ Scribed by Michael A. Wallace; Conrad Raab; Dennis Dean; David Melillo
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- French
- Weight
- 80 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
Lewis acid‐assisted sulfonylation of anisole with [^35^S]methanesulfonyl chloride afforded high specific activity aryl [^35^S]sulfones. Demethylation and treatment with triflic anhydride gave the versatile [^35^S]triflate 1 in good overall yields. The [^35^S]sulfone triflate could be further functionalized by catalyzed aminations, Stille couplings, and cyanation. Copyright © 2007 John Wiley & Sons, Ltd.