Synthesis of 3,5-dideoxy-5-iodo-1,2-O-isopropylidene-β-l-lyxo-hexofuranose derivatives
✍ Scribed by Benoît Rondot; Thierry Durand; Jean-Claude Rossi; Patrick Rollin
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 573 KB
- Volume
- 261
- Category
- Article
- ISSN
- 0008-6215
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Vicinal proton-proton spin-coupling constants for methyl 5-O-acetyl-2-O-benzoyl-3,4-O-isopropylidene-fl-L-idoseptanoside (1) have led to the assignment [1] of the twist-chair conformation, °'ITC2, 3 [2], for the seven-membered ring in 1 in which the pseudo-axis of symmetry passes through C-5. Since
A new sugar, methyl 5-O-benzoyl-2,3-dideoxy-2,3-difluoro-D-lyxofuranoside (8), which features fluorine substituents on adjacent carbon positions above the plane of the tetrahydrofuran ring, was synthesized from 1,2: 5,6-di-O-isopropylidine-alpha-D-allofuranose in seven steps and 22% overall yield. D
Several mono-and bi-cyclic polyhydroxylated alkaloids, isolated from plants', are specific and potent glycosidase inhibitors3, including those involved in the processing of glycoproteins4. Convenient intermediates for the synthesis of these compounds are 5-azido-5-deoxy sugar derivatives. Attempts