Synthesis of 3,4,5,10,11,12-cyclotetradecahexaene-1,8-dione, a monocyclic dicumulenedione
β Scribed by Garratt, Peter J.; Nicolaou, Kyriacos C.; Sondheimer, Franz
- Book ID
- 126216594
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 415 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
In the title compound, C 13 H 15 N 3 O 2 , the triazepane ring adopts a twist-boat conformation and the piperidine ring adopts a boat conformation. The molecular packing is stabilized by N-HΓ Γ ΓO, C-HΓ Γ ΓO, C-HΓ Γ Γ and van der Waals interactions.
A facile approach to pyrazolo [4,3-e][1,4] diazepin-5,8-diones andpyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepin-5,10-diones is reported. Strategy involved the utility of Ξ±-amino acid as a three-atom segment in the construction of diazepine skeleton on the preformed pyrazole ring.