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Synthesis of [3.3.0] bicyclic isoxazolidinyl nucleosides

✍ Scribed by Yuejun Xiang; Raymond F. Schinazi; Kang Zhao

Book ID
104364604
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
216 KB
Volume
6
Category
Article
ISSN
0960-894X

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✦ Synopsis

The isoxazolidine derivative 6, prepared from an intermolecular 1,3dipolar cyeloaddition of the (5S)-unsaturated lactone 5 and N-methylnitrone, was effectively used for the synthesis of [3.3.0] bicyclic isoxazolidinyl cytidine 4a and thymidine 4b.

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