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Synthesis of 3-trifluoromethyl steroids

✍ Scribed by Wolff, Manfred Ernst; Pascual, Abraham F.


Book ID
127280946
Publisher
American Chemical Society
Year
1971
Tongue
English
Weight
571 KB
Volume
14
Category
Article
ISSN
0022-2623

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Synthesis of 3-phenyl-5-(trifluoromethyl
✍ James W. Pavlik; Jennifer A. Lowell; Vuthichai Ervithayasuporn πŸ“‚ Article πŸ“… 2005 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 65 KB

Reaction of 4,4,4-trifluoro-1-phenyl-1,3-butanedione with hydroxylamine led to the formation of 5hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole which was dehydrated to 3-phenyl-5-(trifluoromethyl)isoxazole. This isomer can also be synthesized by reaction of 4-chloro-4-phenyl-1,1,1-trifluo