Synthesis of 3-substituted thieno[2,3-d]pyrimidin-4 (3H)-one-2-mercaptoacetic acids and their ethyl esters for pharmacological screening
✍ Scribed by M. B. Devani; C. J. Shishoo; U. S. Pathak; S. H. Parikh; G. F. Shah; A. C. Padhya
- Book ID
- 102402884
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 454 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3549
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## Abstract A series of new 2‐substituted 3‐(4‐chlorophenyl)‐5,8,9‐trimethylthieno[3′,2′: 5,6]pyrido[4,3‐__d__]pyrimidin‐4(3__H__)‐ones **8** were synthesized __via__ an aza‐__Wittig__ reaction. Phosphoranylideneamino derivatives **6a** or **6b** reacted with 4‐chlorophenyl isocyanate to give carbo
## Abstract The carbodiimides **4**, obtained from reactions of iminophosphorane **3** with aromatic isocyanates, were reacted with secondary amines to give 2‐dialkylamino‐5‐ethyl‐6‐methyl‐thieno[2,3‐__d__]pyrimidin‐4(3__H__)‐ones **6** in the presence of catalytic amount of EtONa. Reactions of **4
## Abstract magnified image The thienopyridine derivative **2**, obtained from reaction of acetoacetic ester with **1** in the presence of tin tetrachloride, was treated with triphenylphosphine in hexachloroethane and Et~3~N to give iminophosphorane **3**. Iminophosphorane **3** reacted with pheny